Aaron Gleeman of NBC's HardBallTalk reported that Pettitte will make his 2012 debut for the Yankees pitching at home against the Seattle Mariners.
Pettitte has been pitching in extended spring training ever since he announced back in March that he was coming out of retirement for the Yankees.
Pettitte accepted a one-year, $2.5 million minor-league deal after he was invited to the Yankees' spring training as a special instructor.
It was there that Pettitte got the urge to pitch again after retiring before the 2011 season.
While in the minors, Pettitte made four starts ranging from Class A, AA and AAA, threw 17 innings with a 13-2 strikeout-to-walk ratio and had a 3.71 ERA, which isn't too bad considering he hasn't thrown a live pitch since Game 3 of the 2010 American League Championship Series.