Hamilton kicked off the scoring with a two-run shot in the top of the first inning off of starter Jake Arrieta. He then proceeded to hit another two-run shot off of Arrieta in the third.
Zach Phillips was the victim of Hamilton's third two-run shot of the night in the seventh inning.
Hamilton hit his historic fourth two-run shot in the eighth off of Darren O'Day.
He stroked a double in the contest as well and went 5-for-5 on the night.
Hamilton joined elite company Tuesday night, becoming the 16th player in history to hit four home runs in a single game.
Elvis Andrus scored on all four of Hamilton's home runs, and he is now third on the Rangers with 19 runs scored.